Beta Cell Toxicity

Discuss the relationship betwixt B-cell toxicity and diabetes type II; what is the role of activated type O species? Type II diabetes, non-insulin dependent, is a progressive disease characterized by insulin resistance and pancreatic B-cell rectify apoptosis which result in hyperglycaemia (Mahan, Escott-Stump, & Ramond, 2012). The resulting hyperglycemia induces, and is exacerbated by irreversible B-cell toxicity, which furthers the disconfirming effects of insulin sensitivity and insulin secretion (Mahan et al., 2012). This is supported by Robertoson, Takahashi, Tanaka, and Tran (2003), whose question indicated that hyperglycemia associated with type 2 diabetes is a secondary power of beta-cell toxicity. B-cell toxicity develops over great exposure to high glucose absorption and results in damage to cellular components of insulin production that effect insulin engrossment and secretion (Robertson et al., 2003). Robertson et al. found that the restroom of B-cell glucose toxicity involves pancreas duodenum homeobox-1 (PDX-1), a critical regulator of insulin promoter activity. Roberson asseverate in vivo, that Zucker diabetic oily (ZDF) rats lost islet B-cell deoxyribonucleic sulfurous binding activity of PDX-1 and insulin cistron expression as they progressively developed more ascetical hyperglycemia.

In the same study, Roberson in like manner notice that PDX-1 and insulin were preserved, and glycemic control was improved when the ZDF rats were case-hardened with either an antioxidant or get down blood glucose levels. These findings suggest that B-cell toxicity is also a here and now of aerophilous stress. Chronic oxidative stress end-to-end the be is often associated with hyperglycemia because the riotous glucose concentrations form reactive group O species (ROS), and increased ROS is common in the pathogenesis of diabetes (Drews, Krippeit-Drews, & Dufer, 2010). B-cells atomic look 18 especially at risk as a grade for ROS. They have oddly low antioxidant defense expertness because they...If you urgency to get a full essay, order it on our website: Ordercustompaper.com

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